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FURA-2AM (CAS 108964-32-5) is a cell-permeable fluorescent calcium indicator widely employed in intracellular Ca measurements through ratiometric fluorescence microscopy Chemically it is the acetoxymethyl ester derivative of FURA-2 enhancing membrane permeability and enabling active transport into live cells Upon cytosolic entry intracellular esterases cleave its ester groups converting it into active FURA-2 which binds free Ca ions with 1 1 stoichiometry Ca binding induces a measurable excitation wavelength shift from 380 nm (Ca -free) to 340 nm (Ca -bound) while emission remains constant around 510 nm FURA-2AM s ratiometric measurement reduces artifacts from cell variability probe leakage and photobleaching making it a standard fluorescent probe in calcium signaling studies
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LP-261 is a potent and orally active anti-mitotic agent. It inhibits in vitro tubulin polymerization with an EC50 of 3.2 μM and demonstrates G2/M block activity across multiple cell lines. LP-261 also inhibits the growth of human non-small-cell lung tumors (NCI-H522) in vivo and is intended for cancer research.
Potent and orally active anti-mitotic agent
Inhibits in vitro tubulin polymerization
Shows G2/M block activity across multiple cell lines
Inhibits growth of human non-small-cell lung tumors
Competes with colchicine for binding to tubulin
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ZTA-261 is a selective thyroid hormone receptor β (THR-β) agonist used in preclinical research on lipid metabolism and obesity. It is provided as a powder for laboratory use and has been characterized for potency and composition.